Hradčany and Lesser Town (Malá Strana)

  • Prague Castle with the St. Vitus Cathedral which store the Czech Crown Jewels
  • The picturesque Charles Bridge (Karlův Most)
  • The Baroque Saint Nicholas Church
  • Church of Our Lady Victorious and Infant Jesus of Prague
  • Písek Gate, one of the last preserved city gate of Baroque fortification
  • Petřín Hill with Petřín Lookout Tower, Mirror Maze and Petřín funicular
  • Lennon Wall
  • The Franz Kafka Museum

Old Town (Staré Město) and Josefov

  • The Astronomical Clock (Orloj) on Old Town City Hall
  • The Gothic Church of Our Lady before Týn (Kostel Matky Boží před Týnem) from 14th century with 80 m high towers
  • The vaulted Gothic Old New Synagogue (Staronová Synagoga) of 1270
  • Old Jewish Cemetery
  • Powder Tower (Prašná brána) a Gothic tower of the old city gates
  • Spanish Synagogue with its beautiful interior
  • Old Town Square (Staroměstské náměstí) with gothic and baroque architectural styles
  • Municipal House, a major civic landmark and concert hall known for its Art Nouveau architectural style and political history in the Czech Republic
  • Museum of Decorative Arts in Prague, with an extensive collections including glass, furniture, textile, toys, Art Nouveau, Cubism and Art Deco
  • Clam-Gallas Palace, a baroque palace from 1713

New Town (Nové město)

  • Busy and historic Wenceslas Square
  • The National Museum with large scientific and historical collections
  • The National Theatre, a neo-Renaissance building with golden roof, alongside the banks of the Vltava River
  • The Dancing House (Fred and Ginger Building)
  • Charles Square, the largest medieval square in Europe
  • The Emmaus monastery and WW Memorial "Prague for his winning children" at Palacky Square (Palackého náměstí)
  • The museum of the Heydrich assassination in the crypt of the Church of Saints Cyril and Methodius
  • Stiassny's Jubilee Synagogue is the largest in Prague
  • The Mucha Museum, showcasing the Art Nouveau works of Alfons Mucha