Hradčany and Lesser Town (Malá Strana)
Prague Castle with the St. VitusCathedral which store the Czech Crown Jewels- The picturesque Charles Bridge (Karlův Most)
- The Baroque Saint Nicholas Church
- Church of Our Lady Victorious and Infant Jesus of Prague
- Písek Gate, one of the last preserved city gate of Baroque fortification
- Petřín Hill with Petřín Lookout Tower, Mirror Maze and Petřín funicular
- Lennon Wall
- The Franz Kafka Museum
Old Town (Staré Město) and Josefov
- The Astronomical Clock (Orloj) on Old Town City Hall
- The Gothic Church of Our Lady before Týn (Kostel Matky Boží před Týnem) from 14th century with 80 m high towers
- The vaulted Gothic Old New Synagogue (Staronová Synagoga) of 1270
- Old Jewish Cemetery
- Powder Tower (Prašná brána) a Gothic tower of the old city gates
- Spanish Synagogue with its beautiful interior
- Old Town Square (Staroměstské náměstí) with gothic and baroque architectural styles
- Municipal House, a major civic landmark and concert hall known for its Art Nouveau architectural style and political history in the Czech Republic
- Museum of Decorative Arts in Prague, with an extensive collections including glass, furniture, textile, toys, Art Nouveau, Cubism and Art Deco
- Clam-Gallas Palace, a baroque palace from 1713
New Town (Nové město)
Busy and historic Wenceslas Square- The National Museum with large scientific and historical collections
- The National Theatre, a neo-Renaissance building with golden roof, alongside the banks of the Vltava River
- The Dancing House (Fred and Ginger Building)
- Charles Square, the largest medieval square in Europe
- The Emmaus monastery and WW Memorial "Prague for his winning children" at Palacky Square (Palackého náměstí)
- The museum of the Heydrich assassination in the crypt of the Church of Saints Cyril and Methodius
- Stiassny's Jubilee Synagogue is the largest in Prague
- The Mucha Museum, showcasing the Art Nouveau works of Alfons Mucha
